Glimepiride + Metformin + Pioglitazone is a combination of three antidiabetic medicines: Glimepiride , Metformin and Pioglitazone. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide.

Hypoglycemia (low blood glucose level), Nausea, Taste change, Diarrhea, Stomach pain, Headache, Edema (swelling), Weight gain, Blurred vision, Bone fracture, Respiratory tract infection

Glimepiride+Metformin+Pioglitazone is used in the treatment of type 2 diabetes mellitus.